Low Dose Naltrexone (LDN) 9ml

Doc Frank

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MSRP: R349.00
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Ignore everything you know about LDN, coz they don't know what they're talking about.

 This is a spray, not a tablet. The reason is simple: 80+% of tablet LDN gets chowed by the liver. A waste of your hard-earned money. 100% of LDN sprayed under the tongue / inside the cheek gets absorbed without passing via the liver. Result: All the benefit at a fraction of the cost.

Put another way: Since naltrexone is largely metabolised by the liver through first pass metabolism, a sublingual spray makes a lot of sense. Less naltrexone is needed and the kinetics are more predictable.

 One 9 ml spray bottle contains 60 mg of LDN = 60 sprays = 60 days' supply. This is a bargain at twice the price. Yay!

Giving a sublingual dose, bypassing the liver, means that there are almost no side effects. Most of the side effects are caused by the breakdown products of LDN passing through the liver.

The nonsense about LDN taking a while to kick in is due to the liver chowing up the useful bits and spitting out side effect causing waste products. Our LDN spray should give you a wow effect within 7 days, possibly shorter. When you find yourself thinking, "I'm feeling so good, this ought to be illegal," then you know it's kicked in.


LDN, or Low Dose Naltrexone, represents a quantum leap in medical treatment.  Naltrexone is commonly used to reverse certain agents used in anaesthesia, as well as in the treatment of opioid overdose, especially herion overdose.  In other words, it has anti-opioid effects.  When given in tiny doses, however (about 2% or less of the conventional doses), it stimulates the production of endorphins by the body.  

Endorphins are the body's own painkillers, and they act on endorphin receptors. These receptors are also the target of opioid drugs, except opioid drugs damage the body's ability to produce endorphins when they link up with the receptors.

Endorphins are the brain's 'laughing hormone'. When you laugh, endorphin levels rise.  When endorphin levels rise, you laugh more easily. It works both ways.,

Endorphins are thus the real anti-depressants. But that is not all. They also stimulate the immune system to work much, much better.

When used in low dose form, Naltrexone can increase endorphin production in the brain by 100 times or more.

Indications and Uses

Low-Dose Naltrexone (LDN) is quickly becoming the preferred treatment for a wide range of Auto-Immune and Chronic Diseases including Multiple Sclerosis (MS), Crohn's, Irritable Bowel Syndrome (IBS), Rheumatoid Arthritis, Myalgic Encephalitis (ME), Chronic Fatigue Syndrome (CFS) and Fibromyalgia, but also in Colitis, Cancer, Autism, Chronic Pain, Depression, Anxiety, Mental Health and more. Here is your opportunity to try it for yourself.


Every 9 ml spray bottle contains 60 x 100 uL sprays = 2 months' supply

Each spray contains 1 mg Naltrexone.

One spray bottle lasts 2 months.

Packaging is professional and each unit is tightly shrink-wrapped.


1 spray under the tongue at 18.00 - 20.00 every night. No later than 22.00.

The need for higher doses of naltrexone (2-4 mg daily) is partially due to increased liver metabolism. Sublingual application of 1 mg is sufficient for most people. In rare situations, it may be helpful to give 2 mg, once daily. There is no need to increase dosage over time. The side effect profile of sublingual application is also a lot better than after oral application.

Cancer patients need to take 1 x LDN spray under the tongue three times daily. This seems to have the best effect.


For the first 3 days, spray LDN under your tongue at 14.00-15.00. Set an alarm. That way, you will avoid the insomnia side effect. From Day 4, spray the LDN under your tongue at 18.00-20.00. That way, you will sleep like a log. By dosing at night (according to my schedule above), you will get maximum endorphin production. More bang for you buck.

Do not swallow, eat, brush teeth or wash out mouth afterwards. Don't kiss your dog goodnight, either.

Giving LDN at other times of day is not nearly as effective and may account for the erratic results often achieved.




LDN spray is best kept refrigerated, but is also stable for long periods (days, even weeks) at room temperature

34 Reviews Hide Reviews Show Reviews

  • 5
    Low Dose Naltrexone

    Posted by Ramon on 20th Nov 2023

    Phenomenal product, works on multiple levels to boost mood (dopamine production), a general booster and is incredibly uplifting for the chronically ill. Helps with my Fibromyalgia - it's the only pharma product I take, all the rest are natural. Says something about LDN !!!!

  • 4

    Posted by Yolanda on 19th Apr 2023

    I have hashimotos, been struggling with inflammation and weight gain. Been using this for 1 month and I have reduced inflammation and have lost 1.5kgs so far. In 7 years and after trying several supplements etc, nothing has reduced my inflammation like this product. Looking forward to the long-term benefit of LDN. Thanks Dr. Frank

  • 5
    Low Dose Naltrexone

    Posted by Carola on 7th Feb 2023

    It took about 3 days to feel the difference but the impact on my energy levels, less pain, less frequent headaches and better sleep is significant!

  • 4
    LDN Seems positive

    Posted by Linda on 7th Nov 2022

    I have only started using, and already feeling a lot better i.e. definitely more positive and less pain in joints. I have Hashimotos and done antibody tests, will measure again in 3 months. Thank you so much for making this available, as I searched everywhere for it :)

  • 5

    Posted by Cape on 14th Aug 2022

    This was a game changer for me. I no longer have chronic fatigue and my joints don’t ache nearly as much as they once used to. I’m using LDN as an immune regulator for Hashimoto’s Thyroiditis.

  • 5
    Excellent product

    Posted by Rene on 22nd Jun 2022

    LDN has helped with my fibromyalgia pain as well as my depression. The fibro pain is not as intense as before and I sleep much better. My mood is also much better since I've been using LDN.

  • 5
    Good product

    Posted by Rosha on 5th Jun 2022

    Great stuff helped with pain

  • 5
    Good product

    Posted by Rosh on 31st May 2022

    I've been on LDN for 10 days and I'm glad to say I have less joint pains and feel in a better space ... Some strange dreams lol thank you Dr Frank

  • 5

    Posted by Peter on 23rd May 2022

    My wife is diabetic and LDN has bought her sugar levels back to normal.

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